Teams of eight runners compete on an 80-mile course. Each runner completes three sections that range in length from 2.5 to 4 miles. Teams are started in groups every 30 minutes beginning at 6:15am and continuing until the last group is started at 8:45am.
The River-to-River Trail as a concept has been a part of the Shawnee National Forest since its beginning. Until recently, however, the trail started from Cave-In-Rock and ended at the crossing of route 45 for a distance of about 80 miles.